Airway hyperresponsiveness is dissociated from airway wall structural remodeling
نویسندگان
چکیده
منابع مشابه
Airway Hyperresponsiveness: From Molecules to Bedside Invited Review: Airway wall remodeling: friend or foe?
McParland, Brent E., Peter T. Macklem, and Peter D. Paré. Invited Review: Airway wall remodeling: friend or foe? J Appl Physiol 95: 426–434, 2003;10.1152/japplphysiol.00159.2003.—Airway wall remodeling is well documented for asthmatic airways and is believed to result from chronic and/or short-term exposure to inflammatory stimuli. Airway wall remodeling can contribute to airway narrowing as we...
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When airways narrow, either through the action of smooth muscle shortening or during forced expiration, the lung parenchyma is locally distorted and provides an increased peribronchial stress that resists the narrowing. Although this interdependence has been well studied, the quantitative significance of airway remodeling to interdependence has not been elucidated. We have used an improved comp...
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BACKGROUND Asthma is a chronic disease that is characterized by airway hyperresponsiveness and airway remodeling. The underlying mechanisms that mediate the pathological processes are not fully understood. Abl is a non-receptor protein tyrosine kinase that has a role in the regulation of smooth muscle contraction and smooth muscle cell proliferation in vitro. The role of Abl in airway hyperresp...
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BACKGROUND Airway inflammation and airway remodeling are the key contributors to airway hyperresponsiveness (AHR), a characteristic feature of asthma. Both processes are regulated by Transforming Growth Factor (TGF)-β. Caveolin 1 (Cav1) is a membrane bound protein that binds to a variety of receptor and signaling proteins, including the TGF-β receptors. We hypothesized that caveolin-1 deficienc...
متن کاملIncreased airway closure is a determinant of airway hyperresponsiveness.
In order to investigate whether increased airway closure is a component of airway hyperresponsiveness (AHR), airway closure was compared during induced bronchoconstriction in 62 asthmatic, 41 nonasthmatic nonobese (control) and 20 nonasthmatic obese (obese) subjects. Airway closure and airway narrowing were measured by spirometry as percentage change in forced vital capacity (%DeltaFVC) and cha...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2008
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2008.05.020